By now, most people familiar with cannabis have heard of THC (tetrahydrocannabinol) and CBD (cannabidiol) and their effects, but did you know there are many similar compounds in cannabis? A lesser-known cannabinoid called cannabigerol (CBG), while not present in large quantities in most strains, is nonetheless worth learning about for a number of reasons.
How is CBG (cannabigerol) made?
Because it is present in low levels (usually less than 1%) in most cannabis strains, CBG is considered a minor cannabinoid. Cannabis plants produce cannabigerolic acid (CBGA), the precursor to the three main cannabinoid lines: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA).
CBG and research on its effects
The research on CBG helps to shed some light into its potential. Below we’ve provided links to some interesting articles:
- In animal experiments involving mice, CBG was studied to explore its potential to treat inflammatory bowel disease.
- A recent 2015 study on CBG claims to help protect neurons in mice with Huntington’s disease, which is characterized by nerve cell degeneration in the brain.
- In a study done on CBG and cancer, CBG was shown to inhibit the growth of colorectal cancer cells in mice, thereby slowing colon cancer growth. According to this study, CBG inhibited tumors and chemically-induced colon carcinogenesis, therefore demonstrating a very exciting possibility for a cure for colorectal cancer.
- European research shows evidence that CBG is an effective antibacterial agent, particularly against methicillin-resistant Staphylococcus aureus (MRSA) microbial strains resistant to several classes of drugs. Since the 1950s, topical formulations of cannabis have been effective in skin infections, but researchers at the time were unaware of the plant’s chemical composition.
- In a very recent 2017 study, researchers showed that a form of CBG purified to remove delta-9 THC was a very effective appetite stimulant in rats. This may lead to a novel non-psychotropic therapeutic option for cachexia, the muscle wasting and severe weight loss seen in late stage cancer and other diseases.
- In a study that looked at the effects of five different cannabinoids on bladder contractions, CBG tested best at inhibiting muscle contractions, so it may be a future tool in preventing bladder dysfunction disorders.
Scientists are excited about these initial CBG results and are promoting future research with CBG alone, or CBG in combination with other cannabinoids and therapies for the treatment of multiple maladies. Because it is non-psychotropic, CBG has a promising wide range of potential applications not only for the problems mentioned above, but also a host of health conditions.