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What is CBC?

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    Frequently Asked Questions About CBC

    Discovered 60 years ago, CBC, cannabichromene, is a cannabinoid being studied for relieving tension, alleviating soreness, and improving wellness. 

    CBC is known to interact with the body's endocannabinoid system. The ECS is responsible for regulating many physiological processes such as appetite, pain, sensation, mood and memory.

     

    CBC also interacts with other receptors, like TRPV1, that can effect how our bodies respond to pain and stress.

    CBC and other cannabinoids like THC and CBD are all found in the cannabis plant, but each have their own unique properties. 

    CBC, like CBD, is non-psychoactive and does not product a "high". However, unlike CBD, CBC does not bind directly to the cannabinoid receptors in the brain, but instead works by enhancing the effects of other cannabinoids. 

    THC is the most well-known and widely studied cannabinoid due to it being responsible for the psychoactive effects of cannabis.

    • Alleviates soreness
    • Relieves tension
    • Improves wellness
    • Supports recovery
    • Mood enhancement
    • Clear skin

    CBC interacts with the ECS by binding to cannabinoid receptors; however, CBC does not bind directly to CB1 or CB2 receptors. 

    In terms of more specific side effects, there have been some reports of mild gastrointestinal discomfort, such as nausea and diarrhea, in some individuals taking CBC. However, these symptoms are generally considered to be rare and mild, and can be easily managed.

    While the 2018 Farm Bill made CBD products legal in The United States, CBC and other CBD products have not received approval from the FDA. 

    Extract Labs is a leader in high-quality CBC products. We offer product types for everyone, such as CBC Capsules or CBC Oil.

    Are you ready to delve into the exciting world of Cannabichromene (CBC)? This lesser-known cannabinoid may not have the same level of notoriety as THC or CBD, but its potential benefits are just as promising. CBC is one of the “big six” cannabinoids that have been the subject of medical research for over 50 years, and it’s about time we shine a spotlight on it. In this blog post, we’ll answer some of the most frequently asked questions about CBC and explore its discovery, properties, and place among the other cannabinoids. So whether you’re a seasoned cannabis connoisseur or just starting to learn about this fascinating plant, buckle up and join us on a journey to discover the enigmatic CBC.

    What is CBC and Where is it Found?

    Discovered over 60 years ago, CBC is considered one of the “big six” cannabinoids prominent in medical research. It doesn’t get as much attention, but CBC’s benefits are extremely promising.

    Cannabichromene (CBC) is a lesser-known but has been the subject of medical research for over 50 years. Discovered in 1964 by Raphael Mechoulam and his team of researchers at Hebrew University in Israel. Despite its potential benefits, CBC remains relatively unknown compared to its more popular counterparts.

    CBC is the third most abundant cannabinoid found in the cannabis plant, after CBD and THC. CBC has the same origins as THC and CBD. They all stem from cannabigerolic acid (CBGa). Cannabis plants produce CBGa, the precursor to other major cannabinoids including tetrahydrocannabinolic acid (THCa), cannabidiolic acid (CBDa), and cannabichromenic acid (CBCa). These are cannabinoids with an acidic tail. With heat, the molecules transform into THC, CBD, and CBC.

    While THC and CBD are the most well-known and popular cannabinoids, there are over 100 others that have yet to be fully discovered and studied. Of the known cannabinoids, CBC is one of the minor ones, alongside CBE, CBF, CBL, CBT, and CBV.

    a hemp field

    How Does CBC Differ From Other Cannabinoids Like THC and CBD?

    CBC, THC, and CBD are all cannabinoids found in the cannabis plant, but they each have unique properties that set them apart from one another.

    THC is the most well-known and widely studied cannabinoid. It is responsible for the psychoactive effects of marijuana, giving users the feeling of being “high”. THC works by binding to the cannabinoid receptors in the brain, resulting in a range of effects including altered perception, mood, and cognitive function.

    CBD, on the other hand, is non-psychoactive and does not produce a “high” associated with THC. Instead, it has been shown to have a range of wellness benefits, including reducing stress and relieving discomfort and tension.

    CBC, like CBD, is also non-psychoactive and does not produce the “high”. It has been observed for its potential benefits. Unlike THC and CBD, CBC does not bind directly to the cannabinoid receptors in the brain, but instead works by enhancing the effects of other cannabinoids, particularly THC and CBD.

    While CBC, THC, and CBD are all cannabinoids found in the cannabis plant, they each have unique properties and effects. CBC and its potential therapeutic benefits are thought to be enhanced when used in conjunction with other cannabinoids like THC and CBD.

    CBC does not bind directly to the cannabinoid receptors in the brain, but instead works by enhancing the effects of other cannabinoids, particularly THC and CBD.

    What are the Potential Therapeutic Benefits of CBC?

    While CBC has singular benefits, researchers believe it works synergistically with other cannabinoids in a phenomenon known as the entourage effect. It’s well-known that CBD and THC enhance each other’s power, but how other cannabinoids play into the entourage effect is not fully understood. However, the purported benefits of CBC have far-reaching implications. So what exactly is CBC oil good for?

    Endocannabinoid Anadamide

    CBC may be beneficial because of how it interacts with the body’s natural endocannabinoid anandamide. Anandamide produces a host of positive functions, most notably mood enhancement and fear reduction. CBC appears to inhibit the uptake of anandamide, allowing it to remain longer in the bloodstream, thus enhancing mood.

    Anxiety and Depression?

    A scientific study researched if CBC and THC may have the potential to help with the symptoms listed above by inhibiting a specific enzyme called LDHA. This inhibition is thought to occur through a non-competitive mode, which means that the CBC and THC are not competing with other substances for the same target. The study also used computer modeling to predict the binding site for CBC and THC and found that both substances may bind in the same area, which is consistent with their non-competitive mode of inhibition. In short, the study researched if CBC and THC may be effective in helping with the symptoms in question by targeting a specific enzyme, LDHA. (2)

    Cancer?

    A study observing the effects of CBC on cancer studied if treatment with a combination of CBC, THC, or CBD may have caused cell cycle arrest and cell apoptosis. In simpler terms, the study researched if a combination of CBC, THC, and CBD may have potential effects on cancer cells (1).

    Inflammation and Pain?

    One study concluded that CBC is a type of cannabinoid that can activate a specific type of receptor in the body (CB2) more effectively than another cannabinoid (THC). It also suggests that CBC can help regulate the activity of this receptor. The study further researched if the presence of CBC in cannabis may contribute to potential therapeutic benefits of some cannabis-based products, particularly through its ability to reduce discomfort by modulating the CB2 receptor. (4)

    Neuroprotection?

    Research studied if CBC can support healthy brain function. This research also observed the potential effects of CBC on neurological conditions such as Parkinson’s, Alzheimer’s, Multiple Sclerosis, and traumatic brain injury (3).

    Extract Labs Tip:

    Have a favorite lotion? Mix in CBC Oil for added wellness benefits and relief.

    Acne?

    A group of researchers who had previously demonstrated CBD’s impact on acne extended their investigations to other cannabinoids, including CBC, aiming to uncover similar effects. Encouragingly, CBC displayed potential capabilities as an acne inhibitor. Acne, a skin condition, is characterized by the overproduction of sebum and inflammation in sebaceous glands. Notably, CBC showcased potentially anti-inflammatory properties and potentially curtailed excessive lipid generation in these glands. Additionally, CBC was observed to lower levels of arachidonic acid (AA), a crucial component in lipogenesis. While further research is warranted, the potential exists for CBC to emerge as a highly effective anti-acne treatment in the future.

    It’s important to note that while these studies suggest potential wellness benefits of CBC, more research is needed to fully understand its effects and potential uses.

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    How Does CBC Interact with the Body's Endocannabinoid System?

    The endocannabinoid system (ECS) is a complex system in the body that plays a key role in regulating a variety of functions, including pain, mood, appetite, and sleep. It’s composed of endocannabinoids, receptors, and enzymes that work together to maintain balance and stability in the body. So, how does CBC fit into all this?

    Well, like other cannabinoids, CBC interacts with the ECS by binding to cannabinoid receptors. Unlike THC, which binds directly to the CB1 receptors in the brain, CBC does not bind directly to either the CB1 or CB2 receptors. Instead, it works by enhancing the effects of other cannabinoids, such as THC and CBD, and by influencing the levels of endocannabinoids in the body.

    It’s like being the conductor of an orchestra – CBC may not play a direct instrument, but it helps to coordinate and enhance the performance of the other cannabinoids, leading to a more harmonious and balanced effect. By working together with other cannabinoids, CBC may help to support the body’s natural processes and promote overall wellness.

    The ECS is a complex system, but understanding how CBC fits into the mix can give us a glimpse into its potential benefits and why it’s an important player in the world of cannabinoids.

    The presence of CBC in cannabis may contribute to potential therapeutic benefits of some cannabis-based products, particularly through its ability to reduce discomfort by modulating the CB2 receptor.

    Are There Any Known Side Effects of CBC?

    When it comes to exploring the world of cannabinoids, it’s important to consider both the potential benefits and any potential side effects. So, what do we know about the side effects of CBC?

    Well, the good news is that CBC is considered to be a relatively safe cannabinoid, with few known side effects. Unlike THC, CBC is non-psychoactive and does not produce the “high” associated with marijuana use. This means that it is unlikely to cause any significant alterations in perception, mood, or cognitive function.

    In terms of more specific side effects, there have been some reports of mild gastrointestinal discomfort, such as nausea and diarrhea, in some individuals taking CBC. However, these symptoms are generally considered to be rare and mild, and can be easily managed.

    It’s important to note that while CBC has a low potential for side effects, everyone’s body is different and individual reactions can vary. As with any substance, it’s always a good idea to consult with a healthcare provider before starting to use CBC, especially if you have any existing medical conditions or are taking any medications.

    While CBC is considered to be a relatively safe cannabinoid with few known side effects, it’s always important to exercise caution and consult with a healthcare provider before starting to use any new substance. And, as with any substance, it’s also important to be mindful of any potential side effects and to report any unusual symptoms to your healthcare provider.

    Is CBC Legal and Available for Medicinal or Recreational Use?

    The legality of CBC can be a bit of a tricky subject, but fear not, we’re here to help you navigate the waters. To start, it’s important to note that the legality of CBC, like other cannabinoids, depends on your location, the purpose of use, and the source of the product.

    In the United States, the 2018 Farm Bill Act legalized the cultivation of hemp, defined as a cannabis plant with less than 0.3% THC. This means that CBC derived from hemp is now legal on the federal level. However, state laws and regulations can vary, so it’s always a good idea to check your local laws before using or possessing a hemp-derived product, including CBC.

    As for medicinal use, CBC has not yet received approval from the U.S. Food and Drug Administration (FDA) for any specific condition. That being said, some states have legalized the use of medical marijuana, which may include CBC, for certain medical conditions. It’s important to check with your state’s laws and regulations to determine the legality of medicinal use of CBC in your area.

    The legality of CBC is a complex issue that depends on many factors, including location, purpose of use, and source of the product. By staying informed about your state’s laws and regulations, you can avoid any legal missteps and make informed decisions about using CBC.

    How is CBC Used in the Production of Cannabis-Based Products?

    CBC Extraction

    CBC extraction is the same process as CBD extraction except with cannabichromene-rich hemp. First, producers pull the raw hemp oil from plant material using CO2. It’s then winterized (separated from unwanted plant material) and decarboxylated (heated to remove the molecule’s carbon tail). Because there is far less CBC in hemp than CBD, extracting CBC is more of a challenge, and most cannabichromene formulas maintain a generous amount of CBD. 

    Unlike CBG, CBN and CBD, cannabichromene does not chemically crystallize into a powdered isolate. Instead, distillate is the most concentrated form of CBC extract.

    Each cannabinoid has its own boiling point, which allows the distiller to separate cannabinoids using vacuum pressure and heat to extract a distillate. While distillate is the closest possible version of pure CBC oil, cannabichromene distillate contains a minuscule amount of other cannabinoids. 

    CBC Products

    Relief Formula CBC Oil Tincture

    One popular method of using CBC is through full-spectrum hemp oil, which contains multiple cannabinoids, including CBC, CBD, and THC. This type of oil is said to produce the “entourage effect,” where the cannabinoids work together to provide a more balanced and effective experience.

    Relief Formula CBC Capsules

    Like our oil formula, CBC softgels contain the same dose of CBC to CBD in each bottle (600 to 1800, respectively). Capsules possess a few benefits, mainly that softgels are pre-dosed, travel-friendly and tasteless.

    Adding CBC Cannabinoids to Your Regimen

    When starting a plant-based wellness routine, it is important to try new things and listen to your body every step of the way. While CBD may be doing the trick on its own, you may find that experimenting with cannabinoids like CBC leads to better results.

    CBC is a promising cannabinoid that is worth considering for its potential benefits. With its non-psychoactive nature and potential for stress relieving, soothing discomfort, and other amazing properties CBC is a valuable addition to the cannabis world. So why not give it a try and see if it works for you? With its potential benefits and a variety of available products, CBC is definitely worth exploring.

    If you have been trying different products to no avail, our team of in-house experts is on standby, ready to answer any and all questions. Whether you are just starting out and looking for answers on what to expect or a CBD expert just looking to refine your routine, we are here!

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    Works Cited

    1. Anis, Omer, et al. “Cannabis-Derived Compounds Cannabichromene and Δ9-Tetrahydrocannabinol Interact and Exhibit Cytotoxic Activity against Urothelial Cell Carcinoma Correlated with Inhibition of Cell Migration and Cytoskeleton Organization.” MDPI, 2021, https://www.mdpi.com/1420-3049/26/2/465. Accessed 23 February 2023.

    2. Martin, Lewis J., et al. “Cannabichromene and Δ9-Tetrahydrocannabinolic Acid Identified as Lactate Dehydrogenase-A Inhibitors by in Silico and in Vitro Screening.” ACS Publications, 2021, https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.0c01281. Accessed 23 2 2023.

    3.Oláh A;Markovics A;Szabó-Papp J;Szabó PT;Stott C;Zouboulis CC;Bíró T; “Differential Effectiveness of Selected Non-Psychotropic Phytocannabinoids on Human Sebocyte Functions Implicates Their Introduction in Dry/Seborrhoeic Skin and Acne Treatment.” Experimental Dermatology, pubmed.ncbi.nlm.nih.gov/27094344/. Accessed 14 Aug. 2023.

    4. Shinjyo, Noriko, and Vincenzo Di Marzo. “The effect of cannabichromene on adult neural stem/progenitor cells.” PubMed, 2013, https://pubmed.ncbi.nlm.nih.gov/23941747/. Accessed 23 February 2023.5. Udoh, Michael, et al. “Cannabichromene is a cannabinoid CB2 receptor agonist.” British Pharmacological Society, 2019, https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14815. Accessed 23 2 2023.

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    CEO | Craig Henderson

    Extract Labs CEO Craig Henderson is one of the country’s top experts in cannabis CO2 extraction. After serving in the U.S. Army, Henderson received his master’s in mechanical engineering from the University of Louisville before becoming a sales engineer at one of the nation’s leading extraction technology companies. Sensing an opportunity, Henderson began extracting CBD in his garage in 2016, putting him at the forefront of the hemp movement. He’s been featured in Rolling StoneMilitary TimesThe Today Show, High Times, the Inc. 5000 list of fastest-growing companies, and many more. 

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