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cbd bioavailability

CBD Bioavailability

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    In the dynamic world of CBD, a plethora of products emerges—CBD drinks, creams—each affecting us differently. What causes the variance when the same CBD amount from a cream differs from a oil? It boils down to bioavailability—the rate of CBD absorption in our system. Understanding this is key as each CBD intake method has a unique bioavailability level crucial for pinpointing the right dose and form for desired effects. The mix-and-match potential of these methods creates a seamless routine.

    CBD Bioavailability FAQ's

    Bioavailability = absorption rate
    Absorption rate is how much of something enters the bloodstream in a given amount of time. 

    The one that works best of course! Experimentation is the key to success and varies for each individual. Although vaping has the highest bioavailability, it may not be preferred by everyone as some individuals may not like inhaling vapor.

    Intravenous CBD, which has a bioavailability of 100%, when taking CBD through an IV dose. The IV dose allows for 100% of the CBD to be actively available. 

    The vape juice cart/pod is the CBD form with the highest bioavailability, with up to 56% absorption rate. When inhaled through vaping, CBD enters the bloodstream even quicker compared to other administration methods.

    Topical CBD is the CBD form with the lowest bioavailability, with less than 5% absorption rate. While CBD topicals remain the lowest bioavailable CBD application, they also offer the most targeted application.

    Research indicates that the consumption of high-fat foods can enhance the absorption of CBD in the body.

    What is bioavailability?

    Bioavailability can be thought of as an absorption rate: how much of something enters the bloodstream in a given amount of time. Each method of taking CBD has a different level of bioavailability, which is important to understand because it helps you determine how much you need to take, and in what form, to ensure a proper dose actually ends up in your system. Without this knowledge, you may not feel the desired effects. Let’s explore the bioavailability of CBD across these common forms of ingestion.

    infographic of Product bioavailability information

    Vaping CBD | CBD Carts and Disposable Vapes

    Bioavailability: 34% – 56%

    Inhaling CBD, whether through vaping or smoking, offers the highest bioavailability at 34% – 56%. The lungs provide ample surface area, excellent permeability, and a direct route into the bloodstream, bypassing digestion and accelerating the process compared to sublingual methods. This quicker intake leads to a faster onset of effects but also results in a shorter-lasting impact compared to other methods.

    Sublingual | CBD Oil Tinctures

    Bioavailability: 10% – 20%

    Using a CBD oil tincture under the tongue offers around 10% – 20% absorption. It’s a top choice for oral intake, as CBD enters the bloodstream faster through the mucosal membrane compared to swallowing. Though studies are limited, the duration of keeping the oil under your tongue impacts absorption rates. For optimal absorption, we suggest holding our oil tinctures for 30+ seconds before swallowing the rest. Longer time under the tongue maximizes the potential for ideal absorption.

    CBD Oral Ingestion | CBD Edibles | CBD Gummies

    Bioavailability: 6% – 19%

    When you swallow CBD, its bioavailability drops to approximately 6% – 19%. The challenge lies in CBD’s limited absorption when ingested, leading to a significant portion being eliminated without impact. Most CBD edibles and beverages follow this ingestion method, showcasing the same absorption rate regardless of the form taken. Despite the lower bioavailability, oral ingestion promises longer-lasting effects—consider it the slow-and-steady approach to CBD intake.

    Topical CBD | CBD Creams and Topicals

    Bioavailability: <5% 

    Traditional CBD creams, balms, and muscle rubs typically offer a low CBD bioavailability, lingering around 5%. It’s crucial to opt for a CBD topical with a high CBD content (backed by lab tests) due to this limited absorption. Despite being the least bioavailable method, topicals offer precise targeting—whatever amount of CBD penetrates goes directly to the specific area requiring relief. As topicals deliver minimal CBD into the system without the need for digestion, users can liberally apply them throughout the day for localized benefits.

    Featured Products

    High & Low Bioavailability Products

    If you’re trying to determine the most suitable option for your needs, whether it be high or low bioavailability, take a look at these products that are popular among customers.

    What's the Best Method of Taking CBD?

    The most effective method is the one that suits you best! Experimentation remains the key to finding your ideal approach. Some already have a preferred method, while others base their choice on the condition they’re addressing. Exploring the varied bioavailabilities can also lead to multiple points of relief—for instance, starting with an oil tincture and adding a gummy for a prolonged effect. While both methods have strengths, delving deeper into CBD bioavailability unveils a wider array of options to guide our CBD choices.

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    CEO | Craig Henderson

    Extract Labs CEO Craig Henderson is one of the country’s top experts in cannabis CO2 extraction. After serving in the U.S. Army, Henderson received his master’s in mechanical engineering from the University of Louisville before becoming a sales engineer at one of the nation’s leading extraction technology companies. Sensing an opportunity, Henderson began extracting CBD in his garage in 2016, putting him at the forefront of the hemp movement. He’s been featured in Rolling Stone, Military Times, The Today Show, High Times, the Inc. 5000 list of fastest-growing companies, and many more. 

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